Topography of putaminal degeneration in multiple system atrophy: A diffusion magnetic resonance study
Identifieur interne : 001176 ( Main/Exploration ); précédent : 001175; suivant : 001177Topography of putaminal degeneration in multiple system atrophy: A diffusion magnetic resonance study
Auteurs : Klaus Seppi [Autriche] ; Michael F. H. Schocke [Autriche] ; Kathrin Prennschuetz-Schuetzenau [Autriche] ; Katherina J. Mair [Autriche] ; Regina Esterhammer [Autriche] ; Christian Kremser [Autriche] ; Armin Muigg [Autriche] ; Christoph Scherfler [Autriche] ; Werner Jaschke [Autriche] ; Gregor K. Wenning [Autriche] ; Werner Poewe [Autriche]Source :
- Movement Disorders [ 0885-3185 ] ; 2006-06-06.
English descriptors
Abstract
There is neuropathologic evidence that, in early stages of the Parkinson variant of multiple system atrophy (MSA‐P), the putamen shows a distinct topographical pathology affecting predominantly the dorsolateral and caudal regions while leaving the rostral to midparts almost intact. We investigated the topographic profile of putaminal degeneration in MSA‐P patients in vivo by means of diffusion‐weighted imaging (DWI), which has been shown to reveal abnormalities in the basal ganglia of patients with MSA‐P compared to patients with PD and healthy controls. For this purpose, regional trace of the diffusion tensor (rTrace(D)) values were determined in the entire, anterior, and posterior putamen in 15 patients with probable MSA‐P, in 20 patients with PD, and in 11 healthy volunteers matched for age and disease duration. MSA‐P patients had significantly higher rTrace(D) values in entire, anterior, and posterior putamen compared to both controls and PD patients. Trace(D) values were significantly higher in the posterior compared to the anterior putamen in the MSA‐P group. There were no significant differences between posterior and anterior putamen in both the control and PD group. Our study demonstrates prominent involvement of the posterior putamen in early disease stages of MSA‐P in vivo by assessing putaminal diffusivity with the help of DWI. © 2006 Movement Disorder Society
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DOI: 10.1002/mds.20843
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2006-06-06">2006-06-06</date><biblScope unit="volume">21</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="847">847</biblScope><biblScope unit="page" to="852">852</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">B95B6BF7FBA7BB52A3621EBC0D17A3DF0B6A08D4</idno><idno type="DOI">10.1002/mds.20843</idno><idno type="ArticleID">MDS20843</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>diffusion‐weighted imaging</term><term>magnetic resonance imaging</term><term>multiple system atrophy</term><term>putamen</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There is neuropathologic evidence that, in early stages of the Parkinson variant of multiple system atrophy (MSA‐P), the putamen shows a distinct topographical pathology affecting predominantly the dorsolateral and caudal regions while leaving the rostral to midparts almost intact. We investigated the topographic profile of putaminal degeneration in MSA‐P patients in vivo by means of diffusion‐weighted imaging (DWI), which has been shown to reveal abnormalities in the basal ganglia of patients with MSA‐P compared to patients with PD and healthy controls. For this purpose, regional trace of the diffusion tensor (rTrace(D)) values were determined in the entire, anterior, and posterior putamen in 15 patients with probable MSA‐P, in 20 patients with PD, and in 11 healthy volunteers matched for age and disease duration. MSA‐P patients had significantly higher rTrace(D) values in entire, anterior, and posterior putamen compared to both controls and PD patients. Trace(D) values were significantly higher in the posterior compared to the anterior putamen in the MSA‐P group. There were no significant differences between posterior and anterior putamen in both the control and PD group. Our study demonstrates prominent involvement of the posterior putamen in early disease stages of MSA‐P in vivo by assessing putaminal diffusivity with the help of DWI. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Autriche</li></country><region><li>Tyrol (Land)</li></region><settlement><li>Innsbruck</li></settlement><orgName><li>Université de médecine d'Innsbruck</li></orgName></list><tree><country name="Autriche"><noRegion><name sortKey="Seppi, Klaus" sort="Seppi, Klaus" uniqKey="Seppi K" first="Klaus" last="Seppi">Klaus Seppi</name></noRegion><name sortKey="Esterhammer, Regina" sort="Esterhammer, Regina" uniqKey="Esterhammer R" first="Regina" last="Esterhammer">Regina Esterhammer</name><name sortKey="Jaschke, Werner" sort="Jaschke, Werner" uniqKey="Jaschke W" first="Werner" last="Jaschke">Werner Jaschke</name><name sortKey="Kremser, Christian" sort="Kremser, Christian" uniqKey="Kremser C" first="Christian" last="Kremser">Christian Kremser</name><name sortKey="Mair, Katherina J" sort="Mair, Katherina J" uniqKey="Mair K" first="Katherina J." last="Mair">Katherina J. Mair</name><name sortKey="Muigg, Armin" sort="Muigg, Armin" uniqKey="Muigg A" first="Armin" last="Muigg">Armin Muigg</name><name sortKey="Poewe, Werner" sort="Poewe, Werner" uniqKey="Poewe W" first="Werner" last="Poewe">Werner Poewe</name><name sortKey="Prennschuetz Chuetzenau, Kathrin" sort="Prennschuetz Chuetzenau, Kathrin" uniqKey="Prennschuetz Chuetzenau K" first="Kathrin" last="Prennschuetz-Schuetzenau">Kathrin Prennschuetz-Schuetzenau</name><name sortKey="Scherfler, Christoph" sort="Scherfler, Christoph" uniqKey="Scherfler C" first="Christoph" last="Scherfler">Christoph Scherfler</name><name sortKey="Schocke, Michael F H" sort="Schocke, Michael F H" uniqKey="Schocke M" first="Michael F. H." last="Schocke">Michael F. H. Schocke</name><name sortKey="Wenning, Gregor K" sort="Wenning, Gregor K" uniqKey="Wenning G" first="Gregor K." last="Wenning">Gregor K. Wenning</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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